Aminoadipate-semialdehyde dehydrogenase

AASDH
Identifiers
AliasesAASDH, ACSF4, LYS2, NRPS1098, NRPS998, aminoadipate-semialdehyde dehydrogenase
External IDsOMIM: 614365; MGI: 2442517; HomoloGene: 71711; GeneCards: AASDH; OMA:AASDH - orthologs
EC number1.2.1.31
Orthologs
SpeciesHumanMouse
Entrez

132949

231326

Ensembl

ENSG00000157426

ENSMUSG00000055923

UniProt

Q4L235

Q80WC9

RefSeq (mRNA)

NM_173765
NM_001377004

RefSeq (protein)

NP_776126
NP_001363933

Location (UCSC)Chr 4: 56.34 – 56.39 MbChr 5: 77.02 – 77.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Aminoadipate-semialdehyde dehydrogenase is a protein that in humans is encoded by the AASDH gene. [5]

Function

This gene encodes a member of the non-ribosome peptide synthetase (NRPS) enzyme family. The encoded protein contains an AMP-binding domain, PP-binding (phosphopantetheine, or pantetheine 4'phosphate-binding) domain and the Pyrrolo-quinoline quinon (PQQ) binding domain. The protein is expressed in several adult tissues.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157426 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055923 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Aminoadipate-semialdehyde dehydrogenase". Retrieved 2017-01-02.

Further reading

  • Wang L, Jil C, Xu Y, Xu J, Dai J, Wu Q, Wu M, Zou X, Sun L, Gu S, Xie Y, Mao Y (2005). "Cloning and characterization of a novel human homolog* of mouse U26, a putative PQQ-dependent AAS dehydrogenase". Mol. Biol. Rep. 32 (1): 47–53. doi:10.1007/s11033-003-2716-4. PMID 15865210. S2CID 26141158.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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