3-Hydroxy-N,N-dimethylphenethylamine

Not to be confused with LSM6.
3-Hydroxy-N,N-dimethylphenethylamine
Clinical data
Other namesLSM-6; LSM6
Routes of
administration		Unspecified[1]
Drug classAdrenergic and serotonergic agent[2]
Identifiers
  • 3-[2-(dimethylamino)ethyl]phenol
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC10H15NO
Molar mass165.236 g·mol−1
3D model (JSmol)
  • CN(C)CCC1=CC(=CC=C1)O
  • InChI=1S/C10H15NO/c1-11(2)7-6-9-4-3-5-10(12)8-9/h3-5,8,12H,6-7H2,1-2H3
  • Key:DZZZXJVECUJDRB-UHFFFAOYSA-N

3-Hydroxy-N,N-dimethylphenethylamine (developmental code name LSM-6) is a drug of the phenethylamine family which was under development for the treatment of mood disorders but was never marketed.[1][2] It is the N,N-dimethylated derivative of meta-tyramine (3-hydroxyphenethylamine).[3] The drug is a naturally occurring constituent of Limacia scanden Lour. and is described as an adrenergic and serotonergic agent.[1][2] It may act as a monoamine releasing agent and/or reuptake inhibitor.[2] LSM-6 has sympathomimetic effects.[2] It was being developed in the 1990s in Malaysia.[1] The drug reached the preclinical research stage of development prior to its discontinuation.[1][2]

See also

References

  1. ^ a b c d e "LSM 6 - AdisInsight". adisinsight.springer.com.
  2. ^ a b c d e f Hwi KK, Lay WB (September 1998). "Pharmacological, electrophysiological and toxicity studies of Limacia scanden Lour. (Menispermaceae)". J Ethnopharmacol. 62 (2): 137–148. doi:10.1016/s0378-8741(98)00045-2. PMID 9741886.
  3. ^ "Phenol, 3-(2-dimethylamino)ethyl-". PubChem. Retrieved 1 March 2025.


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